When not to take HEXALGIN® solution: You should not take HEXALGIN® solution if you suffer from any of the following conditions, as this medicine can cause serious problems in these cases: - known hypersensitivity (allergy) to the active ingredient metamizole, other pyrazolones (eg phenazone, propifenazole) or pyrazolidines (eg phenylbutazone, oxyfenbutazone), as well as to any of the other ingredients - patients with known intolerance to analgesics (analgesic asthma or analgesic intolerance such as urticaria-angioedema). Those patients who respond to analgesics (analgesics) such as salicylates, paracetamol, diclofenac, ibuprofen, indomethacin or naproxen with bronchospasm (bronchospasm resulting in difficulty breathing) or other hypersensitivity reactions. - acute, recurrent hepatic porphyria (a rare metabolic disease) as there is a risk of an attack of porphyria - congenital glucose-6-phosphate dehydrogenase deficiency (a rare metabolic disease) due to a risk of haemolysis (destruction of red blood cells) - impaired bone marrow function (eg after treatment with cytostatics - products or diseases of the haematopoietic system (impaired haematopoiesis) What special precautions should be taken: HEXALGIN® solution contains the pyrazolone derivative metamizole and includes a rare but life-threatening risk of shock (circulatory collapse) and agranulocytosis (a severe disease associated with a significantly reduced number of some white blood cells).